Oloa
Dexamethasone
Fua Fa'atatau
Fa'aletino
Fa'aaliga: pa'epa'e pa'epa'e
Malosi: 1.1283
Liu liusuavai: 262-264°C
Mea fa'apuna: 568.2±50.0°C
Fa'amatalaga Saogalemu
Vaega o lamatiaga: Oloa lautele
Fa'aaogāga
E masani ona faʻaaogaina mo le anti-inflammatory ma anti allergic.E talafeagai mo fa'ama'i rūmatoid ma isi fa'ama'i collagen.
O le Dexamethasone (DXMS) na fa'apipi'iina muamua i le 1957 ma o lo'o lisiina i le WHO Essential Medicines Standard Lisi o se tasi o vaila'au taua mo faiga fa'avae soifua maloloina lautele.
I le aso 16 o Iuni, 2020, na taʻua ai e le WHO o faʻaiʻuga o suʻesuʻega faʻataʻitaʻi muamua i Peretania na faʻaalia ai e mafai e le dexamethasone ona laveaʻiina ola o tagata mamaʻi e maua i le neocoronary pneumonia ogaoga, faʻaitiitia ai le oti e tusa ma le tasi vaetolu mo tagata mamaʻi i ventilator ma e tusa ma le tasi-lima mo tagata mamaʻi i luga. na'o le okesene.
Dexamethasone o se corticosteroid synthetic lea e mafai ona faʻaaogaina e togafitia ai le tele o tulaga, e aofia ai faʻamaʻi rumatika, tulaga o le paʻu, allergies ogaoga, foma, faʻamaʻi faʻamaʻi faʻamaʻi, laryngitis amiotonu, edema cerebral, ma atonu e tuʻufaʻatasia ma vailaʻau faʻamaʻi i tagata mamaʻi. mamapala.E iai le fua faatatau o le maitaga o le C i le Iunaite Setete, lea e manaʻomia ai se iloiloga o le aoga o le vailaʻau e sili atu nai lo aʻafiaga aʻo leʻi mafai ona tuʻuina atu, ma le fua A i Ausetalia, e faʻaalia ai e masani ona faʻaaogaina i fafine maʻitaga. ma e leai se faʻamaoniga o le afaina o le pepe.
A'afiaga fa'afoma'i
Dexamethasone, e lauiloa foi o le flumethasone, fluprednisolone, ma le dexamethasone, o se glucocorticoid.O ana mea e maua mai ai e aofia ai le hydrocortisone, prednisone, ma isi. O ona aʻafiaga faʻafomaʻi e masani lava o le anti-inflammatory, anti-toxic, anti-allergic and anti-rheumatic, ma e masani ona faʻaaogaina i falemaʻi.O lona plasma T1/2 e 190 minute ma le tissue T1/2 e 3 aso.O le maualuga o le toto maualuga o le dexamethasone sodium phosphate poʻo le dexamethasone acetate e oʻo i le l itula ma le 8 itula mulimuli ane pe a maeʻa le tui intramuscular.O le fua faatatau o le fusifusia o le protein plasma o lenei oloa e maualalo ifo nai lo isi corticosteroids.O le anti-inflammatory activity o le 0.75 mg e tutusa ma le 5 mg o le prednisolone.Adrenocorticosteroids, anti-inflammatory, anti-allergic and anti-toxic effects e sili atu le malosi nai lo le prednisone, ma o aʻafiaga o le faʻamauina o le sodium ma le potassium excretion e matua mama lava.
1. Anti-inflammatory effect: E mafai ona faʻaitiitia ma puipuia le tali atu o le tino i le mumū, ma faʻaitiitia ai le faʻaalia o le mumū.Hormones taofia le faaputuputuina o sela inflammatory, e aofia ai macrophages ma leukocytes, i luga o le nofoaga o le mumū ma taofia phagocytosis, faamatuu atu o enzymes lysosomal, ma le tuufaatasia ma le faamatuu atu o mediators vailaau o le mumū.
2. Immunosuppressive aafiaga: e aofia ai le puipuia poʻo le faʻalavelaveina o le tali atu i le cell-mediated immune responses, faʻatuai o faʻamaʻi faʻamaʻi, faʻaitiitia le numera o T lymphocytes, monocytes, ma eosinophils, faʻaitiitia le mafai gafatia o immunoglobulins i luga ole cell receptors, ma faʻalavelaveina le tuʻufaʻatasia ma le tuʻuina atu o interleukins , ma faʻaitiitia ai le liua o T lymphocytes i lymphoblasts ma faʻaitiitia ai le faʻalauteleina o tali puipuia muamua.E faʻaitiitia ai le faʻaogaina o faʻalavelave faʻalavelave e ala i le membrane pito i lalo ma faʻaitiitia ai le faʻaogaina o vaega faʻapipiʻi ma immunoglobulins.
E faigofie ona mitiia mai le GI tract, ma le plasma T1/2 o le 190 minute ma le tissue T1/2 o le 3 aso.Ole maualuga ole toto maualuga e oʻo ile 1 itula ma le 8 itula pe a maeʻa le tui ile intramuscular ole dexamethasone sodium phosphate poʻo le dexamethasone acetate, i le faasologa.O le fua faatatau o le fusifusia o le protein plasma o lenei oloa e maualalo ifo nai lo isi corticosteroids, ma o le anti-inflammatory activity o lenei oloa 0.75 mg e tutusa ma le 5 mg o le prednisolone.
